Gene Reporter Systems
ABclonal Technology TrkA Rabbit pAb
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Enzo Life Sciences AMPINEXT™ Post-Bisulfite DNA Library Preparation Kit (Illumina) (24Reactions)
The AMPINEXT™ Post-Bisulfite DNA Library Preparation Kit is a complete set of optimized reagents to prepare a DNA library -- after successful bisulfite conversion -- for various Illumina platform-based bisulfite sequencing (bisulfite-seq) assays, such as whole genome bisulfite sequencing (WGBS), oxidative bisulfite sequencing (oxBs-seq), reduced representation bisulfite sequencing (RRBS), and other bisulfite-based next generation sequencing applications. The optimized protocol and components of the kit allow both non-barcoded (singleplexed) and barcoded (multiplexed) DNA libraries to be quickly constructed using sub-nanogram input concentrations of DNA since the DNA is first bisulfite-converted and then used for library preparation. Assay Time: 5 hours.
Takara Bio RetroNectin® Recombinant Human Fibronectin Fragment, 0.5 mg
A chimeric peptide of recombinant human fibronectin fragments produced in E. coli, consisting of three functional domains: a central cell-binding domain (type III repeat, 8–10), heparin-binding domain II (type III repeat, 12–14), and a CS1 site within the alternatively-spliced IIICS region. It is a 574 amino acid protein with a molecular weight of 63 kDa. When coated on the surface of containers such as culture dishes, petri dishes, flasks or bags, RetroNectin significantly enhances retrovirus-mediated gene transduction into mammalian cells. This enhancement is hypothetically due to colocalization of retroviral particles and target cells on the molecules of RetroNectin. Virus particles bind RetroNectin via interaction with heparin-binding domain II, and target cells bind mainly through the interaction of the cell surface integrin receptor VLA-4 with the fibronectin CS1 site. 0.5mg
ABclonal Technology CYP2D6 Rabbit mAb
This gene encodes a cytochrome P450 enzyme, part of a superfamily of monooxygenases involved in drug metabolism and the synthesis of cholesterol, steroids, and lipids. The protein, located in the endoplasmic reticulum, metabolizes up to 25% of commonly prescribed drugs, including antidepressants, antipsychotics, analgesics, and antiemetics. The gene is highly polymorphic, with certain alleles causing a poor metabolizer phenotype, where individuals have reduced drug metabolism. Some poor metabolizers carry two null alleles or lack the gene entirely. Individuals with the ultrarapid metabolizer phenotype may have three or more active gene copies. Multiple isoforms result from alternative splicing.
Genscript Corporation VEGF R2/KDR mFc Chimera Human
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA VEGFB and PGF and plays an essential role in the development of embryonic vasculature the regulation of angiogenesis cell survival cell migration macrophage function chemotaxis and cancer cell invasion The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis
System Biosciences LLC AAVS1 SAFE HARBOR SITE TARGETI
AAVS1 Safe Harbor Site Targeting Knock-in HR Donor Vector 2.0 (AAVS1-SA-puro-EF1α-MCS)
ABclonal Technology SGK1 Rabbit pAb
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
ABclonal Technology SGK1 Rabbit pAb
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Medchemexpress LLC HER4 Human HEK293 50ug
HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart central nervous system and mammary gland development It is critical for myocardial differentiation postnatal cardiomyocyte proliferation neural crest cell migration axon guidance and mammary gland function HER4 Protein Human (HEK293 His-Fc) is the recombinant human-derived HER4 protein expressed by HEK293 with C-hFc C-10 His labeled tag
Revvity Health Sciences Inc britelite plus Reporter Gene Assay System, 1000 mL
britelite plus Reporter Gene Assay System, 1000 mL
ABclonal Technology ROCK1 Rabbit pAb
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
Biolegend PE/Dazzle™ 594 anti-human CD309 (VEGFR2) [A16085H]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 25 tests
PE/Dazzle™ 594 anti-human CD309 (VEGFR2) [A16085H]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 25 tests